Safety and mutagenicity evaluation of Vigiis 101 powder made from Lactobacillus paracasei subsp. paracasei NTU 101

Wei-Ting Tseng,Tsung-Wei Shih,Shing-Hwa Liu,Tzu-Ming Pan

Regulatory Toxicology and Pharmacology（2015）

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摘要

•Vigiis 101 powder was non-mutagenic in the Ames assay.•The powder had no activity in an in vitro chromosome aberration assay.•Vigiis 101 was non-genotoxic in an in vivo mouse micronucleus assay.•The NOAEL for Vigiis 101 in a 28-day rat study was at least 5g/kgbw/day.

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关键词

Lactobacillus paracasei subsp. paracasei NTU 101,Probiotic,No observed adverse effect level

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