LuSens: a keratinocyte based ARE reporter gene assay for use in integrated testing strategies for skin sensitization hazard identification.

•The LuSens assay uses a human keratinocyte ARE reporter cell line.•The LuSens addresses a key step of the adverse outcome pathway of skin sensitization.•The LuSens provides the same readout as KeratinoSens™; both can be used equivalently.•The test battery comprised of LuSens, DPRA and h-CLAT attained a predictivity similar to LLNA.