Total synthesis of pachastrissamine together with its 4-epi-congener via [3,3]-sigmatropic rearrangements and antiproliferative/cytotoxic evaluation.

Miroslava Martinková,Eva Mezeiová,Milica Fabišíková,Jozef Gonda,Martina Pilátová,Ján Mojžiš

Carbohydrate Research（2015）

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摘要

•The total synthesis of pachastrissamine and its 4-epi-congener was accomplished.•The cornerstone of this strategy was a [3,3]-heterosigmatropic rearrangement.•Crystallographic analysis of a key structure was performed.•A series of synthesized compounds was evaluated for the anticancer activity.

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关键词

Anhydrophytosphingosines,Jaspine B,Pachastrissamine,[3,3]-Heterosigmatropic rearrangements,Stereoselective synthesis,Anticancer activity

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