SNARE-ing the structures of Sec1/Munc18 proteins.

Julia K Archbold,Andrew E Whitten,Shu-Hong Hu,Brett M Collins,Jennifer L Martin

Current Opinion in Structural Biology（2014）

Cited 28|Views12

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Abstract

•Sec1/Munc18 (SM) proteins are essential for SNARE-mediated membrane fusion.•All SM proteins characterized to date have three domains organized into an arch-shape.•SM proteins are dynamic: domain 1 rotates by ∼50° and domain 3a bends by ∼180°.•Three binding sites for partner proteins have been characterized structurally.•How the highly plastic SM proteins regulate membrane fusion remains a mystery?

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Key words

sec1/munc18 proteins,snare-ing

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