The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes

Pia Rantakari,Kaisa Auvinen,Norma Jäppinen,Maria Kapraali,Joona Valtonen,Marika Karikoski,Heidi Gerke,Imtiaz Iftakhar-E-Khuda,Johannes Keuschnigg,Eiji Umemoto,Kazuo Tohya,Masayuki Miyasaka,Kati Elima,Sirpa Jalkanen,Marko Salmi

Nature immunology（2015）

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摘要

PLVAP is a blood vessel endothelium marker of uncertain function. Salmi and colleagues demonstrate that PLVAP is also expressed on lymphoid endothelial cells, where it regulates the entry of antigen and lymphocytes into the lymph nodes.

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nature immunology, science

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