黄芩素纳米混悬液的生物利用度研究
Journal of China Pharmaceutical University(2011)
Abstract
采用反溶剂重结晶结合高压均质法制备黄芩素纳米混悬液,并对其在大鼠体内的生物利用度进行研究.对大鼠分别灌胃给予等剂量黄芩素原料和黄芩素纳米混悬液,采用HPLC法测定活性代谢产物黄芩苷在大鼠体内的血药浓度,利用DAS 2.0软件计算药代动力学参数.结果表明,灌胃给予等剂量黄芩素原料和黄芩素纳米混悬液(121 mg/kg)后,大鼠血浆中黄芩苷的血药浓度-时间曲线均呈现双峰现象,cmax分别为7.18和11.12 μg/mL,tmax分别为1.67和0.92 h,AUC0-24h分别为71.40和118.63μg·h/mL.以黄芩素原料做参比,黄芩素纳米混悬液经口给药后的相对生物利用度为166.1%.黄芩素纳米混悬液可显著提高黄芩素口服给药的生物利用度.
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Key words
Baicalein,Baicalin,Bioavailability,Nanosuspension,Pharmacokinetics
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