Tolerance Of Nestin(+) Cholinergic Neurons In The Basal Forebrain Against Colchicine-Induced Cytotoxicity

In the present study we injected colchicine into the lateral ventricle of Sprague-Dawley rats to investigate the effects of colchicine on the number of different-type neurons in the basal forebrain and to search for neurons resistant to injury. After colchicine injection, the number of nestin(+) cholinergic neurons was decreased at 1 day, but increased at 3 days and peaked at 14-28 days. The quantity of nestin(-) cholinergic neurons, parvalbumin-positive neurons and choline acetyl transferase-positive neurons decreased gradually. Our results indicate that nestin(+) cholinergic neurons possess better tolerance to colchicine-induced neurotoxicity.