2种不同基质的伤湿止痛膏的经皮渗透实验研究
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica(2011)
Abstract
目的:以伤湿止痛膏中马钱子碱、士的宁和硫酸阿托品累积透过率为考察指标,研究新、旧2种不同基质的伤湿止痛膏的体外透皮特性.方法:利用改良扩散池进行体外透皮试验,用HPLC测定透皮接受液中马钱子碱、士的宁和硫酸阿托品含量.结果:新基质(热熔压敏胶)伤湿止痛膏中马钱子碱、士的宁和硫酸阿托品在72 h内平均累积透过率分别为53.25%,74.52%,34.32%;旧基质(天然橡胶)伤湿止痛膏中马钱子碱、士的宁和硫酸阿托品平均累积透过率分别为54.90%,50.24%,46.54%.结论:新基质较旧基质更利于亲脂性药物的释放,且释放更稳定.
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Key words
Bases,Patches Shangshi Zhitong,Percutaneous permeability
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