Cytotoxicity of [Tyr3]octreotide labeled by radionuclide in vitro
Chinese Journal of Medical Imaging Technology(2011)
Abstract
Objective: To observe the cytotoxicity of 131I-[Tyr3]octreotide ( 131I-TOC) to cells involved in the process of Graves ophthalmopathy. Methods: 131I-TOC was added to cells in different growth cycle and different cells to assess the toxicity of 131I-TOC to cells. Then the separate dosage of 131I-TOC was cocultured with fibroblast NIH3T3 and the cytotoxicity was measured. Results: 131I-TOC had significant cytotoxicity to active fibroblast cells and proliferating cells. Its cytotoxicity was enhanced with increased dosage. Conclusion: 131I-TOC might become an effective novel therapy of Graves ophthalmopathy.
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Key words
Cytotoxicity, immunologic,Graves ophthalmopathy,Iodine isotopes
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