Endothelial cell migration was impaired by irradiation-induced inhibition of SHP-2 in radiotherapy: an in vitro study.

The response of endothelial cells to radiation in the context of wound healing is not yet completely understood. In this study we investigated the mechanism involved in the wound healing process after low linear energy transfer (LET) radiation exposure. A scratch wound model on primary vascular endothelial cell monolayer was exposed to acute dose of 0.1, 2 or 10 Gy. The number of cells crossing th...