Cr(VI) with curcumin and hydrogen peroxide causes DNA damage
Remote Sensing, Environment and Transportation Engineering（2011）
Abstract
DNA conformational change and breakage induced by Cr(VI) and curcumin in the present of H2O2 were characterized by the atomic force microscopy. Incubation of DNA with curcumin and Cr(VI) in the presence of H2O2 caused DNA double-strand breaks significantly. Cr(VI) and H2O2 also breaked mildly DNA double-strands. On the basis of these results, we think hydroxyl radicals and reactive oxygen species can play a principal role in this DNA damage system.
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Key words
atomic force microscopy,dna damage,cr(vi) double-strand,hydrogen compounds,biological techniques,dna double strand breakage,biochemistry,molecular biophysics,molecular configurations,atom-molecule reactions,free radicals,hydrogen peroxide,dna conformational change,h2o2,hydroxyl radical,incubation,curcumin,dna breakage,dna,molecule-molecule reactions,reactive oxygen species,dna break,chromium,cr,force,metals
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