The Effect of Pecan Oil on Hippocampal Cells Apoptosis of Ovariectomized Rats

Pecan oil is an edible pressed oil extracted from the pecan nut; it contains approximately 90% unsaturated fat. Previous study showed that unsaturated faty had potent antioxidant activity. Oxidative stress is a pathological change which is higher in postmenopausal women. In the present study, we reported the apoptosis inhibition of hippocampal cells by pecan oil in ovariectomized rats. And the results showed that the pecan oil has protective effect on hippocampal cell apoptosis induced by ovariectomized operation. The mechanism of action could be related to enhancement of the antioxidant activity and adjustment of Caspase-3 expression.