Effects of the fibroblast-myocyte in cardiac electromechanical coupling: A preliminary simulation study
Hangzhou（2011）
摘要
The heart consists of myocytes, vasculature cells and connective tissue cells. In this study, two ventricular electromechanical models were coupled with the fibroblast model. At the cellular level, Niederer-Smith (NS) model of rat ventricular myocyte and ten Tusscher model of human ventricular myocyte and the passive fibroblast model are combined with Rice model of contraction and cooperativity mechanisms. At the tissue level, excited conduction is integrated with elastic mechanics. Numerically, the finite difference method solves the excitation equations, and the finite element method settles the equations governing tissue mechanics. The results showed that fibroblasts slow down wave propagation and increase mesh contraction. The influence of fibroblasts on cardiac excitation and contraction should be pursued in future heart modeling studies.
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关键词
myocytes,cooperativity mechanisms,cardiac excitation,cellular biophysics,cardiology,fibroblast-myocyte,tusscher model,heart modeling study,finite difference method,mesh generation,ns model,tissue mechanics,cellular level,cardiac contraction,rice model,ventricular electromechanical models,physiological models,wave propagation,tissue level,niederer-smith model,vasculature cells,finite element method,passive fibroblast model,preliminary simulation study,biological tissues,finite difference methods,connective tissue cells,rat ventricular myocyte,cardiac electromechanical coupling,excitation equations,human ventricular myocyte,fibroblasts,elastic mechanics,mesh contraction,computer model,couplings,mathematical model,computational modeling,connective tissue,heart
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