Synthesis of n-(3-cyano-7-ethoxy-1,4-dihydro-4-oxoquinolin-6-yl)acetamide

Qiang Zhang,Yongjun Mao,Zheng Liu,Kai Xie,Yi Zhu,Yabing Bing Wei,Xiangrui Jiang,Jingshan Shen

HETEROCYCLES（2011）

引用 15|浏览13

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摘要

New route for the preparation of N-(3-cyano-7-ethoxy-1,4dihydro-4-oxoquinolin-6-yl)acetamide (1), a key intermediate for the synthesis of selective EGFR kinase inhibitors, was described.

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关键词

3-Cyanoquinoline,Synthesis,Reductive Cyclization,Condensation,Process

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