CuI/PPh3/PEG-Water: An efficient catalytic system for cross-coupling reaction of aryl iodides and alkynes
SYNTHETIC COMMUNICATIONS（2011）
Abstract
An efficient protocol for the copper-catalyzed Sonogashira coupling of aryl iodides with terminal acetylenes in water-polyethylene glycol has been established. Both electron-rich and electron-deficient aryl iodides were arylalkynated under microwave heating or reflux in oil bath to afford good to excellent yields.
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Key words
Alkynation,aqueous chemistry,copper,coupling,microwave-assisted chemistry
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