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Dual colored mesoporous silica nanoparticles with pH activable rhodamine-lactam for ratiometric sensing of lysosomal acidity.

Shuqi Wu,Zhu Li,Jiahuai Han,Shoufa Han

CHEMICAL COMMUNICATIONS（2011）

Cited 127|Views6
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Abstract
Alteration of lysosome acidity has been implicated in many biological events ranging from apoptosis to cancer metastasis, etc. Mesoporous silica nanoparticles doped with acid activable rhodamine-lactam and fluorescein isothiocyanate (FITC) were developed for ratiometric sensing of lysosomal pH changes in live cells with flow cytometry.
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Key words
silica nanoparticles,lysosomal acidity,rhodamine-lactam
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