Bioactive Compounds From The Fern Lepisorus Contortus
JOURNAL OF NATURAL PRODUCTS(2011)
Abstract
Phytochemical investigation of the whole plant of Lepisorus contortus (Christ) Ching led to the isolation of five new phenylethanoid glycosides (1-5), each containing a caffeoyl group, a new flavonoid glycoside (10), and 14 known compounds (6-9 and 11-15, syringic acid, vanillic acid, phloretic acid, diplopterol, and beta-sitosterol). This is the first report of phenyl-ethanoid glycosides from the family Polypodiaceae. Compounds 1-15 were evaluated for their calker chemopreventive potential based on their ability to inhibit tumor necrosis factor alpha (TNF-alpha)-induced NF-kappa B activity, nitric oxide (NO) production, and aromatase, quinone reductase 2 (QR-2), and COX-1/-2 activities. Quercetin-3-O-beta-D-glucosicle (15) demonstrated inhibition against QR2 with an IC50 value of 3.84 mu M, which confirmed kaempferol/quercetin glycosides as the active compounds to inhibit QR2. The compound also demonstrated NF-kappa B activity with an IC50 value of 33.6 mu M. In addition, compounds 1, 2, 4, and 6 showed aromatase activity with IC50 values of 30.7, 32.3, 26.8, and 35.3 mu M, respectively.
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compounds
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