Mild and efficient iodine-catalyzed direct substitution of hydroxy group of alcohols with c- and n-nucleophiles

A mild and efficient iodine-catalyzed direct substitution of hydroxy group of allylic, progargylic and other alcohols with various C-and N-nucleophiles was described in this contribution. C-C and C-N bond formations could be readily achieved by non-metallic and green catalysis for various compounds. This facilitates access to possible transformations of a broad scope of substrates into bioactive and pharmaceutically important building blocks.