Neobavaisoflavone-mediated TH9 cell differentiation ameliorates bowel inflammation

Jufeng Guo,Chenxiao Qiao,Jun Zhou,Shufang Hu,Xia Lin,Yingying Shen, Ziyan Li,Jian Liu

International Immunopharmacology（2021）

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摘要

•Neobavaisoflavone suppresses the IL-9 production of CD4+ T cells in vitro.•Neobavaisoflavone decreases TH9 cell differentiation in a PU.1 dependent manner.•Neobavaisoflavone alleviates DSS-induced colitis.•Neobavaisoflavone protects mice from colitis by targeting TH9 cells.•Neobavaisoflavone inhibits human TH9 cell differentiation in vitro.

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关键词

Neobavaisoflavone,Inflammatory bowel disease,TH9 cell,PU.1

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