Genotype and haplotype determination of interleukin (IL) 1β (g. -511C>T and g. +3954C>T) and IL-1RN in polycystic ovary syndrome
Fertility and Sterility(2010)
Abstract
The distribution of genotype frequencies, allele frequencies, and haplotype frequencies of variable number of tandem repeats (VNTR) in interleukin (IL) 1RN and IL-1β (-511C > T, exon-5C.>T) polymorphism demonstrated a positive association with the occurrence of polycystic ovary syndrome (PCOS). The carriage of allele V of IL-1RN and allele E1 of exon-5 on the IL-1β gene may increase the risk of PCOS. © 2010 American Society for Reproductive Medicine.
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