Induction Of Cytochrome Cyp4f3 In Hydroquinone-Treated Hl-60 Cells

Cytochrome P450 4F3 (CYP4F3) catalyzes the inactivation of leukotriene B4 by.-oxidation in human neutrophils. Here, we examined the mRNA and protein expression of the CYP4F3 in HL-60 cells, an acute promyelocytic leukemia cell line, in the presence of hydroquinone(HQ). We found hydroquinone led to a decrease in cell proliferation and a increase in cell apoptosis in a dose-dependent and time-dependent manner, it also most strongly induced the expression of the CYP4F3. CYP4F3 appears to be responsible for the cell proliferation and cell apoptosis, which may be play a role in the toxicity of hydroquinone.