Synthesis and characterization of N-[(4-Bromo-3, 5-difluorine) phenyl] acrylamide

Under the catalysis of triethylamine, acryloyl chloride reacted with 4-Bromo-3, 5-difluoroaniline for 4 h at 0°C to yield N-[(4-Bromo-3, 5-difluorine)phenyl]acrylamide. The chemical structure of the product was confirmed by means of FT-IR, 1H NMR, 13C NMR and mass spectroscopy. Various influencing factors on the reactions were also investigated and discussed. The optimum reaction conditions were found as follows: ω(TEA) = 1.15%, reaction temperature 0°C, reaction time 4 h, molar ratio of n(acryloyl chloride) to n(4-Bromo-3, 5-difluoroaniline) of 1.1. Under these conditions, the yield of N-[(4-b romo-3, 5-difluorine)phenyl]acrylamide was 62.5%.