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三维适形放疗联合介入治疗原发性肝细胞癌

廖小方,何慧娟,周正仕,胡伟,朱小平

Journal of Practical Oncology（2010）

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Abstract
目的 探讨失去手术机会的原发性肝细胞癌采用肝动脉化疗栓塞(TACE)后采用三维适形放疗(3DCRT)的疗效和毒副反应.方法 对48例原发性肝细胞癌中24例患者采用TACE+3DCRT(综合组)治疗.24例患者单纯TACE(对照组)治疗.TACE采用肝动脉灌注5-FU、DDP、ADM加碘油栓塞治疗.3DCRT采用6MV-X线,PTV 40～66 Gy/20～33 F,分割次剂量2～2.5 Gy.结果 综合组近期有效率(CR+PR)为82.6%,对照组为54.5%,两组差异有统计学意义(P=0.042).1、3年生存率综合组74.0%、30.0%,对照组50.0%、14.0%,两组差异有统计学意义(P=0.036).不良反应发生率差异无统计学意义.结论 三维适形放疗联合介入治疗原发性肝细胞癌有一定的疗效,是安全有效的治疗方法.
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Key words
Antineoplastic combined chemotherapy protocols,Carcinoma hepatocellular,Chemo-embolization,Conformal,Hepatic artery,Radiotherapy,Retrospective studied,Therapeutic
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