The expression of MGMT and ErbB2 in human glioma

Sun Chun-ming,Wang Zhi-min,Zheng Shi-ying,Xu Qi-nian,Shiming Zhang,Dai Zhou,Youxin Zhou

Sanya（2009）

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摘要

This study was comparison of MGMT and ERBB2 expression in human gliomas. RT-PCR method was used to determine the mRNA levels of MGMT and ErbB2 gene in 42 clinical glioma specimens,There was significant concordance between the expression of MGMT and ErbB2 (p < 0.01). MGMT and ErbB are highly remarkably related each other. The results suggest that there may be in relationship among MGMT and ErbB2 expression in human gliomas which affect DNA repair resulting in drug resistance.

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关键词

DNA,cellular biophysics,drugs,genetics,molecular biophysics,patient treatment,proteomics,tumours,DNA repair,ErbB2,MGMT,RT-PCR method,drug resistance,gene,human glioma,mRNA levels,Drug-resistance gene,Glioma,RT-PCR

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