Revised Structure Of Penicillazine And Preparation, Bioactivities Of Penicillazine Derivatives
Letters in Organic Chemistry（2009）
Abstract
The structure of penicillazine has been revised on the basis of hydrolysis reaction. Its absolute stereochemistry has been confirmed by X-ray diffraction using copper radiation. Eight new penicillazine derivatives (1-8) were prepared and some of them showed higher levels of activity than penicillazine against glucosidase and Human DNA topoisomerase I.
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Key words
Penicillazine,derivatives,structure revision,biological activities,alpha-glucosidase,Human DNA topoisomerase I
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