Expression of nuclear factor κB in the tissuses of chorion of early spontaneous abortion

Objective: To examine the cellular distribution and expression, activation of nuclear factor κB (NF-κB) in the tissuses of chorion of early spontaneous abortion, and explore the relationship between early spontaneous abortion and NF-κB. Methods: The NF-κB expression on the chorionic villi was analyzed by S-P immunohistochemistry. The nucleoplasmic ratio of NF-κB was detected by laser scanning confocal microscope. Results: The expression intensity of NF-κB in the syncytiotrophoblasts was significantly weaker in women with early spontaneous abortion than in the normal early pregnancy (P<0.001). Significant difference existed in the nucleoplasmic ratio of NF-κB expression in stromal cells of chorionic villi between early spontaneous abortion (0.7602) and normal early pregnancy (0.6977) (t=3.511, P<0.001). Conclusion: Low expression of NF-κB in stromal cells of chorionic villi and the excessive activation of NF-κB in villus stromal cells are significantly correlated with the occurrence of early spontaneous abortion.