Eleven Single Nucleotide Polymorphisms (Snps) Were Found At Coding Region Of Hypocretin Receptor1 (Hcrtr1) Gene In Cattle

Abstract. The hypocretin receptor1 (HCRTR1) gene encodes a Orexin A receptor (SAKURAI et al., 1998). It belongs to the class Ι subfamily within the superfamily of G-coupled receptors and is coupled to Ca2+ mobilization. Via HCRTR1, Orexin A is involved in the control of feeding, sleep-wakefulness, neuroendocrine homeostasis and autonomic regulation (VOISIN et al., 2003; TAKESHI SAKURAI, 1999). These characters are important in animal production. In human, a 408 isoleucine to valine mutation in HCRTR1 showed significant association with polydipsic–hyponatremic schizophrenia (MEERABUX et al., 2005). By now, no polymorphisms of the bovine HCRTR1 gene were reported.