Inhibitory effects of compounds isolated from fruit of Juglans mandshurica on pancreatic lipase

The water extract of Juglans mandshurica fruit has been shown to strongly inhibit pancreatic lipase in vitro in a dose-dependent manner. The extract was observed to inhibit the normal elevation in the level of plasma triacylglycerol in rats 2–4 h after oral administration of a lipid emulsion. Fourteen compounds isolated from J. mandshurica fruit were evaluated for their inhibitory activity against pancreatic lipase. Of these, 1,4,8-trihydroxynaphthalene-1- O -β- d -[6′- O -(3″,4″,5″-trihydroxybenzoyl)]glucopyranoside ( 1 ) showed the strongest inhibitory activity.