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华北地区汉族群体15个短串联重复序列基因座遗传多态性分析

Xin-ping FAN,Jie DING,Yan LIANG,Bai XIAO,Yan ZHOU,Jing-zhong LIU

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics（2006）

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Abstract
目的调查华北地区汉族人群15个短串联重复序列(short tandem repeat, STR)基因座遗传多态性分布和群体遗传学数据. 方法应用毛细管电泳技术和五色荧光复合扩增的方法,检测597名汉族无关个体的15个STR基因座基因型. 结果 15个STR基因座的基因频率分布均符合Hardy-Weinberg平衡,所检测的15个STR遗传标记均具有高度多态性,杂合度均超过0.62,15个基因座的个体识别力在0.802～0.967之间,非父排除率在0.320～0.697之间,匹配概率在0.033～0.198之间.15个基因座的累积个体识别能力为0.999999以上,累积非父排除率为0.99999571,累积匹配概率为8.93×10-18. 结论联合检测15个基因座可为亲缘鉴定和个体识别提供可靠的法医学证据,这15个STR基因座适用于中国人群的法医物证学检验.
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Key words
Allele frequency,Genetic polymorphism,Short tandem repeat
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