Enantioselective Total Synthesis of 12-Carboxyeudesma-3, 11 (13)-diene

The enantioselective total synthesis of 12-carboxyeudesma-3,11(13)-diene (1) was achieved starting from (-)-dihydrocarvone in ten steps for the first time. The key steps mainly include the introduction of hydroxyl group into C-12 position of eudesmane by Vilsmeier chlorination and the generation of C3-C4 double bond into the eudesmane skeleton by elimination of halide.