The studies of serum CVB-specific IgM antibody and nitric oxide among the patients with latent and chronic Keshan disease

Objective: To investigate the serum coxsackie virus B(CVB) infection and nitric oxide (NO)level of the patients suffer from latent or chronic Keshan disease and their characteristics in the etiopathology of Keshan disease. Methods: Sera were isolated from 30 patients with latent or chronic Keshan disease in Huangling county. Shaanxi Province, and the CVB-specific IgM antibody and NO were tested. Control groups were health subjects in Huangling county or Xi'an city, Shaanxi Province. Results: The percentage of CVB-specific IgM positive in patients in Huangling county was significantly higher than that of both control groups in Huangling county and Xi'an city(P<0.05). The serum level of NO in patients was significantly higher than that of the control group in Huangling county (P<0.05),however, compared with control group in Xi'an city, there was no difference (P>0.05). In CVB-specific IgM positive patients, the serum level of NO was significantly higher than that of CVB-specific IgM negative group (P<0.05). Conclusion: CVB infection and serum NO level might be related to the etiopathology and the development of Keshan disease.