Synthesis Of Demethoxy-Amino-Substituted Hypocrellins: Novel Photosensitizers For Photodynamic Therapy

A novel method was used to obtain demethoxy-amino-substituted hypocrellin derivatives. Peri-hydroxylated perylenequinone structure of hypocrellin was reserved when hypocrellin reacted with an amine in pyridine. The products were new compounds with significant cytoxicity against tumor cells. Their structures have been established on the basis of their mass and H-1 NMR spectra.