Comparative Studies On The Mechanism Of Uridine Phosphorolysis

ShanHong Zhao,Kaixian Chen,Hualiang Jiang,Qinmi Wang,Ruyun Ji

CHINESE JOURNAL OF CHEMISTRY（1997）

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摘要

We have used quantum mechanical method to study the transition states(TSs) of uridine phosphorolysis reaction. Comparing the four different reaction pathways and the five transition states obtained, we conclude that enzymatic uridine phosphorolysis takes place mainly according to acid-catalyzed S(N)2 mechanism. The proposed reaction pathway is consistent with many experimental results.

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关键词

transition state, uridine phosphorolysis, reaction mechanism, nucleophilic substitution, intrinsic reaction coordinate

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