LC-MS/MS法鉴定替米沙坦氨氯地平双层片中有关物质
Journal of China Pharmaceutical University（2014）
Abstract
建立LC-MS/MS法对替米沙坦氨氯地平双层片的有关物质进行鉴定.双层片中的替米沙坦层及氨氯地平层分别取样和反相高效液相色谱线性梯度法分析测定,替米沙坦及氨氯地平均与其有关物质分离良好.检测出替米沙坦中14个有关物质峰,对其中主要7个有关物质经二级质谱测定和解析鉴定了它们的结构,同时检测出氨氯地平中2个为英国药典收载的有关物质.
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Key words
Identification,LC-MS/MS,Related substances,Telmisartan/amlodipine double layer tablets
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