Comparison of manual and semi-automated segmentation methods to evaluate hippocampus volume in APP and PS1 transgenic mice obtained via in vivo magnetic resonance imaging.

Kerrie Hayes,Richard Buist,Trevor J Vincent,Jonathan D Thiessen,Yanbo Zhang,Handi Zhang,Junhui Wang,Arthur R Summers,Jiming Kong,Xin-Min Li,Melanie Martin

Journal of Neuroscience Methods（2014）

引用 12|浏览12

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摘要

•A semi-automatic and a more accurate manual method were developed to detect difference in volumes of hippocampus between mice.•The semi-automated segmentation was unable to detect the same level of differences.•Manual segmentation is a more reliable segmentation method for small structures.

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关键词

MRI,Alzheimer's disease,Hippocampus,Transgenic mouse models,Volume,Segmentation

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