Studying on Extraction of Betulin from the White Birch and Synthesis of Betulinic Acid
Lecture Notes in Electrical Engineering(2014)
摘要
Betulin and betulinic acid are natural product with antitumor and anti-HIV-1 activity. Betulin can be got by chemical extraction from a lot of plants. Betulinic acid can be synthesized from betulin. In order to get high biological activity compounds with antitumor and anti-HIV-1 activity from the bark of the white birch, the extraction and purification method of betulin was studied; the optimized extraction and purification condition was obtained. The two-step synthetic routes of betulinic acid from betulin were discussed. Betulinic acid was synthesized by oxidizing betulin with Jones reagent, followed by selective reduction with NaBH4. IR, HPLC–MS, H1-NMR were used to identify the structure of betulin and betulinic acid.
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关键词
Betulin,Extraction,Betulinic acid,Synthesis
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