Design and synthesis of novel 20-substituted hydroxycamptothecin derivatives
Lecture Notes in Electrical Engineering(2014)
Abstract
Camptothecin (CPT) is a potent antitumor alkaloid isolated in 1966 by M.E. Wall. Clinical use of camptothecin in cancer therapy, however, was limited by its poor water solubility. Recently, there is a growing tendency to develop some new methods for the synthesis of novel derivatives to solve the problem. In this paper, we'd like to report the design and synthesis of a novel series of 20-substituted Hydroxycamptothecin to increase the water solubility. All the five products have never been reported before. All the products and important intermediates were characterized by 1HNMR and LC-MS spectra. ? Springer-Verlag Berlin Heidelberg 2014.
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Key words
hydroxycamptothecin derivatives,water solubility
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