Protective effects of flavonoids from lotus leaf against exercise-induced oxidant stress in muscle of mice

The main purpose of this study was to examine the effect of flavonoids from Lotus leaf (FFL) on exercise-induced oxidant stress in mice. 32 mice were randomly divided into 4 groups: control group, FLL low dose treated group, FLL middle dose treated group and FLL high dose treated group. The control group was given distilled water and the treated groups were given different doses of FLL (50, 100, 150 mg/kg) by gavage once a day for 28 days. 28 day later, mice were made to swim until being exhausted, and exhaustive swimming time, malondialdehyde (MDA) levels, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in muscle were measured. The data showed that that FFL increase the exhaustive swimming time and could elevate the exercise tolerance, as well as decrease the MDA levels, increase SOD and GSH-Px activities in muscle of mice. These results indicated that FFL has a protective effect against exercise-induced oxidative stress..