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MiR-215 modulates gastric cancer cell proliferation by targeting RB1.

Yujie Deng,Zhenxia Huang,Yanjun Xu,Juan Jin,Wei Zhuo,Cheng Zhang,Xuting Zhang,Minhong Shen,Xiaoyi Yan,Liangjing Wang,Xiaojia Wang,Yibin Kang,Jianmin Si,Tianhua Zhou

Cancer Letters（2014）

Cited 82|Views28
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Abstract
•MiR-215 is frequently up-regulated in gastric cancer and may serve as a biomarker for diagnosis.•Inhibition of miR-215 suppresses gastric cancer cell proliferation via G1 arrest.•MiR-215 targets RB1 through its 3′-UTR in gastric cancer cells.•RB1 is involved in the role of miR-215 in modulating gastric cancer cell proliferation.
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Key words
Gastric cancer,MiR-215,Retinoblastoma,Proliferation
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