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藤甲酰苷的合成及抗肿瘤活性研究

王洋,张启景,刘举,刘洋,韩爽,张秋实,陈烨,周云鹏

Chinese Journal of New Drugs（2013）

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Abstract
目的:合成藤甲酰苷并进行抗肿瘤活性研究.方法:以藤黄树脂为起始原料提取藤黄酸,通过6步反应合成了具有抗肿瘤活性化合物藤甲酰苷并对其抗肿瘤活性进行了初步筛选.结果与结论:目标产物结构经1 H-NMR和ESI-MS确证,NCI体外细胞实验结果显示藤甲酰苷对美国国立肿瘤研究所选用的59种人癌肿瘤细胞均有效,对其中22种有明显的抑制作用.
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Key words
Antitumor,Gambogic acid,Gareinia glycosides,Synthesis
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