Effect Of Food On The Single-Dose Pharmacokinetics And Tolerability Of Clinofibrate Tablets In Chinese Healthy Volunteers

The aim of this study is to investigate a food effect on the single-dose pharmacokinetics and tolerability of clinofibrate tablets in 12 Chinese healthy volunteers. The authors evaluated the effect of being under a fasting or fed state at the time of drug intake on the single-dose of clinofibrate 400 mg tablets in a randomized, balanced, single-dose, two-treatment (fed and fasting), two-period, two-sequence study design with a 7-day washout period. The end points were the maximum plasma drug concentration (C-max) and areas under the plasma-concentration curve (AUC) for 72 hours exposure (AUC(0-72)) and total exposure (AUC(0-infinity)). All participants completed the whole study without side effects being observed. The C-max mean of clinofibrate glucuronides and parent clinofibrate were 21.91, 17.85 mu g/ml for the fasting state and 13.14, 11.25 mu g/ml for the fed state, respectively. The AUC(0-72) and AUC(0-infinity) of clinofibrate glucuronides and parent clinofibrate were 381.60, 307.07 mu g/ml and 404.55, 342.24 mu g/ml for the fasting state and 379.02, 321.14 mu g/ml and 432.24, 351.80 mu g/ml for the fed state. The authors showed that food intake was associated with a significant decrease in C-max but no significant change in AUC values.