血清和胃液PⅢNP、LN在胃癌辅助诊断中的价值
World Chinese Journal of Digestology(2013)
Abstract
目的:探讨胃液、血清中层黏连蛋白(laminin,LN)、Ⅲ型前胶原氨端(N-terminal procollagen Ⅲpeptide,PⅢNP)含量的检测在胃癌辅助诊断中的价值.方法:采用放射免疫法测定50例胃癌患者、25例癌前病变患者胃液和血清中PⅢNP和LN含量,以46例浅表性胃炎患者作为对照.结果:胃癌组患者胃液中PⅢNP含量显著高于癌前病变组和对照组(40.49 μg/L±39.07μg/L vs 8.49 μg/L±5.45 μg/L,7.38 μg/L±6.13μg/L,均P<0.01),LN的水平也显著高于癌前病变组和对照组(131.61 ng/mL±55.71 ng/mLvs 90.92 ng/rmL±58.36 ng/mL,80.65 ng/mL±59.43 ng/mL,P<0.05; P<0.01);胃癌组血清中PⅢNP含量明显高于癌前病变组和对照组(55.38 μg/L±25.13 μg/L vs41.56 μg/L±18.27μg/L,39.89 μg/L±13.07 μg/L,均P<0.05),LN的水平亦显著高于对照组(158.62 ng/mL±42.70 ng/mL vs 126.25 ng/mL±36.18 ng/mL,P<0.01).胃液PⅢNP和LN单独检测对胃癌诊断的敏感性分别为68.00%、66.00%,二者联合检测其敏感性为86.00%.进一步分析显示,伴有淋巴结或器官转移的患者胃液和血清中PⅢNP和LN水平高于不伴有转移的患者;PⅢNP和LN水平与病理分级相关,低分化腺癌患者胃液、血清中PⅢNP和LN含量高于高分化腺癌患者.结论:胃液及血清PⅢNP和LN含量的检测在胃癌的辅助诊断中有一定临床价值.
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Key words
gastric cancer,gastric juice,laminin,n-terminal peptide,procollagen iii,serum
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