Assessment of capsule endoscopy scoring index, clinical disease activity, and C-reactive protein in small bowel Crohn's disease.

Background and Study Aims Small bowel Crohn's disease (SBCD) patients are frequently assessed by capsule endoscopy (CE), which enables direct visualization of small bowel mucosal abnormalities; however, the correlations between CE scoring index (CESI), C-reactive protein (CRP), and disease activity indices remain undefined. We aimed to determine correlations between the CESI, clinical disease activity indices, and CRP in SBCD patients. Patients and Methods A prospective study was conducted between October 2008 and February 2011 on 58 established SBCD patients and suspected patients who received a definitive SBCD diagnosis during study. Patients underwent complete CE and were scored according to the CESI and HarveyBradshaw index (HBI). Statistical correlation among CESI, HBI, and CRP was assessed. Results Weak, but significant, correlations were found between CESI and HBI (r=0.4, P<0.01). The correlation between CESI and CRP was moderate (r=0.58, P<0.01). The median CRP value was significantly higher in patients with moderate to severe CESI compared with the mild group (22.60 +/- 16.79mg/Lvs 11.88 +/- 8.39mg/L, P<0.01). Changes between baseline and follow-up CESI failed to correlate with the delta-HBI or delta-CRP (both, 0.05). Conclusions In this cohort of SBCD patients, clinical disease activity index was not reliable predictors of mucosal inflammation. CRP, however, might be a useful inflammatory marker for evaluating the moderate to severe CE activity in SBCD patients. Furthermore, therapy-induced clinical and biological improvement was not associated with repair of SBCD mucosal lesions.