Telaprevir fragments as organocatalysts in asymmetric direct aldol reactions of aldehydes
Russian Journal of General Chemistry(2014)
摘要
We have demonstrated that the fragments of Telaprevir can act as organocatalysts for asymmetric aldol reactions between aromatic aldehydes and acetone under mild conditions. The reaction conditions have been optimized in terms of the catalyst nature, choice of temperature, solvent, additive, and the catalyst loading. Under proper conditions, fairly good yield and enantioselectivity have been achieved.
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关键词
General Chemistry,Aromatic Aldehyde,Catalyst Loading,Enantiomeric Excess,Telaprevir
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