The synthesis of benzo[f]isoindole-1,3-dicarboxylates via an I 2-induced 1,3-dipolar cycloaddition reaction
JOURNAL OF ORGANIC CHEMISTRY(2013)
摘要
An I-2-induced 1,3-dipolar cycloaddition reaction has been developed for the synthesis of benzo[f]-isoindole-1,3-dicarboxylates from quinones and N-substituted amino esters. The reaction proceeds in good to excellent yields in one step from 3 equiv of amino ester to react with the quinone structure. The utility of this transformation has been highlighted by its use for the construction of benzo[f]-isoindole-1,3-dicarboxylates, which have been identified in natural products exhibiting important biological activities.
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关键词
cycloaddition reaction,synthesis,cheminform abstract
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