Nickel-catalyzed reductive cross-coupling of aryl halides
SYNLETT(2013)
摘要
This work highlights unsymmetrical biaryl compounds via direct nickel-catalyzed reductive coupling of two aryl halides. By tuning the ligand structures, the reaction of two electron-enriched aryl halides also provided the coupling product in good yields, with an excess of 1.4 equivalents of one of the halides. The mild reaction conditions display excellent functional-group tolerance and generally gave the coupling products in moderate to good yields. In addition to aryl bromides, activated aryl chlorides are effective.
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关键词
nickel,cross-coupling,biaryl,aryl halides
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