Synthesis and antitumor-evaluation of 1,3-selenazole-containing 1,3,4-thiadiazole derivatives

Hai-Chuan Zhao,Yan-Ping Shi,Yu-Ming Liu,Cai-Wen Li,Li-Na Xuan,Peng Wang,Kai Zhang,Bao-Quan Chen

Bioorganic & Medicinal Chemistry Letters（2013）

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摘要

New series of 1,3-selenazole-containing 1,3,4-thiadiazole derivatives bearing Schiff base moieties 6(a–k) were synthesized. The newly synthesized compounds were evaluated for their in vitro antiproliferative activities against MCF-7 and L1210 cells by CCK-8 assay.

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关键词

1,3-Selenazole,1,3,4-Thiadiazole derivatives,Schiff base,Antitumor agents

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