肺癌患者血清中RCAS1水平及其临床意义

Journal of Practical Oncology(2013)

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Abstract
目的 探讨肺癌患者血清中SiSo细胞表达的受体结合肿瘤抗原(RCASl)水平并进行分析,为临床诊治提供依据.方法 采用酶联免疫吸附试验(ELISA)分别检测90例肺癌患者、60例良性肺部疾病患者和102名健康体检者血清RCAS1水平,并进行比较分析.结果 肺癌组血清RCAS1水平与良性肺疾病组和健康对照组比较差异有统计学意义(P<0.05);随病程进展肺癌患者RCAS1的阳性率逐步升高,肺癌Ⅲ、Ⅳ期患者RCAS1阳性率(82.8%、95.8%)明显高于Ⅰ、Ⅱ期患者(42.9%、56.5%)(P值均<0.05);有淋巴结转移的患者RCAS1阳性率(80.6%)明显高于未转移患者(44.4%)(P<0.05).RCAS1诊断肺癌的敏感度为73.3%,特异性为96.9%,准确性为88.5%.结论 RCAS1对肺癌的辅助诊断有一定的临床价值,可以作为一项新的肺癌标志物应用.
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Key words
Diagnosis,Enzyme-linked immunosorbent assay,Lung neoplasms,Receptor-binding cancer antigen expressed on SiSo cells,Tumor markers, biological
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