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SIRT5 desuccinylates and activates SOD1 to eliminate ROS.

Zhi-Feng Lin,Hong-Bing Xu,Jian-Yun Wang,Qiang Lin,Zhen Ruan,Fa-Bing Liu,Wang Jin,Hai-Hua Huang,Xi Chen

Biochemical and Biophysical Research Communications（2013）

Cited 192|Views22
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Abstract
•SOD1 is succinylated and the succinylation decreases its activity.•SIRT5 binds to, desuccinylates and activates SOD1.•Mutation of SOD1 succinylation site inhibits the growth of lung tumor cells.
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Key words
SIRT5,Succinylation,Antioxidation,ROS,Cell growth
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