Involvement of a chromatin modifier in response to mono-(2-ethylhexyl) phthalate (MEHP)-induced Sertoli cell injury: probably an indirect action via the regulation of NFκB/FasL circuitry.

Shiwei Chen,Yushu Dong,Chun Xu,Liming Jiang,Yongjie Chen,Cheng Jiang,Wugang Hou,Wei Li

Biochemical and Biophysical Research Communications（2013）

引用 13|浏览4

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摘要

•MTA1 expression is upregulated in SCs upon MEHP treatment.•Knockdown of MTA1 in SCs impairs the MEHP-induced NFκB signaling activation.•Knockdown of MTA1 inhibits recruitment of NFκB onto FasL promoter in MEHP-treated SCs.

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关键词

Nuclear factor-κB (NFκB),Metastasis associated protein 1 (MTA1),Mono-(2-ethylhexyl) phthalate (MEHP),Sertoli cell,Fas/FasL

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